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    In this episode of the Active Ingredients podcast, host Thomas Dove interviews John Tomtishen, Cell and Gene Therapy Executive Leader and Recognised CMC Expert

    John Tomtishen has spent over a decade in cell and gene therapy, helping deliver the first approved CAR-T therapy at Novartis, building the CMC strategy behind Legend Biotech’s Carvykti, and now leading global field application and strategic alliances at Catalent.

    In this conversation, he shares the three principles- authenticity, integrity and self-sacrifice- that carried him from a 118,000-person pharmaceutical company to his role as Legend Biotech’s fifth US employee and into a leading CDMO. He explains why empowerment must precede accountability, what separates a high-performing team from a cohesive one, and his three pillars of career success.

    Click or tap the play button to watch the video or tune in on Spotify, Apple Podcast or Amazon Music.

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    Key Takeaways

    • Learn why John Tomtishen treats authenticity, integrity and self-sacrifice as the foundation of every team he builds.
    • Discover why a cohesive team beats a high-performing one, and how non-verbal cues keep results consistent over months, not weeks.
    • Understand why empowerment must come before accountability, and how stepping back strengthens delivery under pressure.
    • Explore Tomtishen’s three pillars of career success: what you know, who you know, and the pillar he rates highest, how you’re known.
    • Apply the lesson behind Kymriah’s approval, captured in his mantra “the process is the product,” to any team building manufacturing capability.
    • Gain a grounded view of AI in leadership, where technology supports the work but face-to-face relationships still drive results.
    • Uncover why celebrating small wins keeps teams motivated through the long, high-pressure journey of commercialising a cell therapy.
    • Identify the two factors that decide commercial success against 70-plus rivals: time to market and product quality.

    Snippets

    • “I think there’s three principles I’m always driven by: authenticity, integrity and self-sacrifice… to lead a team, you have to be willing to take the bullet for your team.”
    • “A high-performing team can last a month or two. A truly cohesive team consistently maintains that performance over time, and can anticipate things before you even say them.”
    • “There’s three pillars I’ve always viewed career success as defined by: what you know, who you know, and how you’re known. The most important pillar is how you’re known.”

    Timestamps & Topics

    The following timestamps are approximations:

    • [01:26] – Active Ingredients: John Tomtishen’s three foundational leadership principles
    • [04:20] – Origin Story: How a research project pulled him into cell therapy
    • [08:52] – Pivotal Moment: The Novartis lab experience that made him a leader
    • [27:30] – Empowerment: Why accountability starts with letting go of oversight
    • [29:14] – Team Cohesion: The difference between high-performing and truly cohesive
    • [40:28] – Career Framework: What you know, who you know, how you’re known
    • [44:14] – AI Readiness: Using technology without losing the human connection

    Resources

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