On the Active Ingredients podcast, I speak with life science leaders about the lessons the job actually taught them, both hard-won and the ones that came easily. I recently hosted Dr R Ananthanarayanan (Ananth), global biopharma and healthcare executive and former Chief Executive Officer of Teva’s active pharmaceutical ingredients business. We talked about how he built commercial skills on top of a PhD after being turned down for a sales role, and how to tell resistance from real insight when you inherit teams across borders. Tune into the full podcast episode on YouTube, Spotify, Apple Podcasts or Amazon Music.
Of everything we covered, one hard-won lesson stood out. Most people see a fast answer as the mark of a seasoned leader. Ananth doesn’t, and increasingly, nor do the hiring boards we work with. In this article, we look at how defining the problem statement first helps senior leaders make better decisions.
Experience is supposed to make the answer obvious. You have run sites, steered products through launch and solved most problems at least twice, so acting fast feels earned. Then a plan that worked at your last organisation falls flat the moment you apply it to a similar scenario in your new role.
The Problem: Why Senior Leaders Act on the Wrong Problem
Senior leaders in pharmaceutical, biotech and medtech organisations are hired for their track record. The trouble is that pattern recognition, the skill that won the job, can work against you in a new setting. Indeed, research into leadership transitions found that between 27 and 46 per cent of executive moves are seen as failures or disappointments two years (McKinsey, 2018).
Ananth admits he has had to learn this himself. “Experienced leaders can sometimes become victims of their own experience… you’ve seen problems before. So you immediately recognise a pattern and then you think you know the answer,” he told me. “But then the problem may not actually be the same.”
Under pressure in a new role, many executives reach for what worked last time. Anish Mehta made a similar kind of move himself, from a divisional role at a public company to chief executive of a private equity-backed business. He told me that making “two pretty big changes at one time” was “not easy in the beginning”. When the problem has never been properly defined, the organisation ends up carrying out a confident plan on the wrong target. In a 2017 Harvard Business Review survey of 106 C-suite executives, 85 per cent agreed their organisations were bad at problem diagnosis, and 87 per cent said the flaw carried high costs. In life sciences, where getting even a simple manufacturing change approved can take more than five years (ISPE, 2020), that mistake is expensive and slow to surface.
So why does this keep happening? The deeper issue is that the problem people describe in your first week is rarely the full picture. As Ananth put it, “very often the problem and the ambiguity is made out to be where it really is not.”
The Solution: Define the Problem, Then Move Fast
Step 1: Ask for the Problem Statement Before Anything Else
When Ananth steps into a new role, his first move is a question rather than a plan. “The first question I would ask is what is the problem statement?” he said. “Because when you have a problem statement, you know the true area that you need to focus on.”
Ananth has made a habit of taking on roles where the organisation “wasn’t even completely sure what it needed”, and he treats that gap as the place to start rather than a reason to hesitate. The same goes for pushback. When someone says no, his instinct is to “take a step back. That seems to be an opportunity there. So let’s look at it and let’s look at defining the problem statement.”
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Step 2: Keep Asking Until You Reach the Real Problem
Ananth calls this peeling back the onion layers. The first answer you hear is often a symptom, so you keep going. “You need to go deeper. You need to keep asking questions; you need to keep checking,” he told me. Aditi Singh Ulvskjold uses questions in a similar way with specialist teams. Rather than learning every technical detail, she asks them to “unearth for me what will drive the impact.”
Ananth is clear that this is not a case against process. “I’m not trying to say that… structured process is not right. It is important, it is good,” he said. “But… very often a problem may be sitting somewhere else, and it may be completely oblivious to you.”
Once he finds the real problem, Ananth sizes it up before acting. In his words, you decide whether “this problem looks humongous, or this problem is small, or this problem is medium, and then how do you break it into bite-sized pieces?”
Step 3: Say “I Don’t Know Yet” and Take the Next Step
Ananth is direct about uncertainty. “Get comfortable saying, I don’t know yet… you don’t need to have certainty before you begin,” he said. “Because if you have certainty before you begin, you’re also starting with a presumption and a fixed way of looking.”
What you need instead, Ananth said, “is enough clarity to take the next intelligent step… which is where I think good leaders distinguish between uncertainty and paralysis.” In practice, that means you “acknowledge uncertainty and still move forward. Don’t wait for every single element to be clear before you move to the next step.”
Step 4: Slow Down to Understand, Then Speed Up to Execute
The pause Ananth recommends is short and has one purpose. “I’ve had to learn to slow down at the beginning of some very important decisions,” he told me. “Not to slow the decision down, but to make sure that you understand the problem correctly.”
Once the problem statement is clear, the pace changes. “Once you have clarity, actually begin moving in quite decisively and quite quickly,” he said. “So slow down to understand, speed up to execute.”
When the pressure is high, Ananth separates the emotion from the decision with a few plain questions: “What are the facts? What is within our control?… What decision has to be made now… what is urgent and critical? What is nice to have?” Breaking a tense situation down this way, he said, makes it “significantly more manageable.”
He pairs this with a line he has repeated to his leadership teams for years: fail fast to succeed sooner. A failure that surfaces late “delays your process of success.” He also sets clear limits on how much can go wrong, so his teams know where the freedom to fail starts and stops.
The Evidence: What Changes When the Problem Comes First
The first change is practical. When you fix the true problem, Ananth explained, the bigger problem it was feeding gets fixed too. The wider change is in how a leadership team treats uncertainty. “Ambiguity isn’t always the absence of opportunity,” he said. “Sometimes or most of the time, ambiguity itself is the opportunity.” Deanna Angello found the same when she took on commercial leadership roles that nobody else wanted. The uncertain situations others avoided became the ones that moved her career forward.
Ananth has taken the same view of ambiguity into roles with almost no structure at all. When he moved his family from India to the US to run a business, he arrived as “employee number one”, building a team and a customer base at the same time. “It can’t get more ambiguous than that,” he said.
He traces the habit back to his scientific training, which gave him “respect for facts and for understanding an underlying problem.” When it is done well, a leadership team can state its problem in one sentence, admit what it does not yet know and then move quickly once it does.
Your Next Move
I came away from our conversation planning to start my own big decisions with the problem statement. Before your next major call, whether it is a site investment, a portfolio cut or a senior hire, ask yourself:
1 Can I write the problem in one sentence that my leadership team would sign up to? If not, that is the first job.
2 Which part of this looks familiar from my last role, and what would have to be true for it to be a different problem this time?
3 Where am I waiting for certainty I will never get, and what is the next intelligent step I could take this week?
4 When did someone last tell me the real problem sits somewhere else? If the answer is never, am I asking the right people?
Dr R Ananthanarayanan’s full conversation on the Active Ingredients podcast covers more ground, including the advice from his first manager to always send the elevator back down, and why he calls himself a cautious optimist.
Fraser Dove International helps life science organisations find leaders who define the problem before they act. If you are hiring for a role where the problem is not yet fully defined, we would be glad to talk.
Connect with Dr R Ananthanarayanan on LinkedIn.
Thomas Dove, CEO
Thomas Dove is CEO and Co-Founder of Fraser Dove International. As host of the Active Ingredients podcast, Thomas interviews senior executives and industry pioneers to uncover the insights that drive successful life science organisations.
Through his work in executive search and the hosting the Active Ingredients podcast, Thomas has developed deep expertise in identifying the leadership qualities that distinguish exceptional life science executives. He regularly writes about talent acquisition strategies, leadership development, and the evolving challenges facing C-suite professionals in the rapidly changing life sciences.
Thomas is passionate about helping life science professionals navigate their career journeys and supporting organisations in building leadership teams that can drive innovation and growth. His insights stem from years of working closely with senior leaders across the pharmaceutical, biotechnology, and Medical Device industries.
Outside the office, he champions family values, positive energy, and his beloved Chelsea FC.
* This article is based on an interview from the Active Ingredients podcast. Hosted by Thomas Dove, the Active Ingredients Podcast dissects the very essence of exceptional leadership in the life sciences. Subscribe to the Active Ingredients podcast on Spotify, Apple Podcasts, Amazon Music and YouTube.
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